Imam Muhammad al-Baqir (a.s) was born in the 58th year of the Hijra, on the third day of the month of safar, in the city of Medina. His honoured father is Imam Sajjad and his revered mother, Fatema, daughter of Imam Hassan (a.s). Imam Sajjad (a.s), according to the command of Allah and the decree of the prophet, appointed his son, Imam Muhammad al-Baqir, to Imamate and leadership of the people, and introduced him as such.

Imam Muhammad al-Baqir (a.s), like the other Imams, in knowledge and science had no equal. Great learned men benefited from his knowledge and science and used to ask him to solve their problems.

Imam Muhammad al-Baqir (a.s) instructed people in percepts of religion, taught them the ethics of life, and used to strive very hard to educate, culture and guide the people. During the course of his life, he taught the people thousands of theological and religious principles, as well as scientific subjects, and his teachings have been handled down to us. His wisdom and learning was so much that he was called Baqir ul-ulum, which means "the opener of sciences".

Imam Muhammad al-Baqir (a.s), lived in this world for a period of 57 years, and in the 114th year of the Hijra, on the seventh day of the month of Zul-Hijjah, in Medina he left this world. His body was buried in Baqi cemetry alongside the graves of Imam Hassan and Imam Sajjad (a.s) in Medina.